If your OCD hasn't improved after SSRIs and exposure and response prevention (ERP) therapy, ketamine may be worth considering. At Village TMS in Manhattan, ketamine for OCD is supervised in person by board-certified psychiatrists, not delivered by rotating technicians. It's used specifically for treatment-resistant OCD, the cases where standard care hasn't brought relief. Research, including studies tracking Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores, shows that some patients experience a measurable reduction in obsessions and compulsions within hours to days, a very different timeline from the weeks SSRIs typically take.
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Dr Fradkin helped me with treatment-resistant depression using TMS.
Valery Dinner Verified Google ReviewI had a great experience at the Village TMS Center for Autism and Depression. The staff is very kind, professional, and truly cares about their patients. They take the time to listen and explain the treatment process clearly.
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Raul Ifraimov Verified Google ReviewTMS session with George went great. Even though I just started and it’s a new experience for me, a cautious supervision and guidance of the specialist helps to get through. I had all my questions being answered before the procedure. Will come again!
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Sofia Dro Verified Google ReviewDr Fradkin helped me with treatment-resistant depression using TMS.
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Ketamine therapy is a modern psychiatric treatment that uses low,
carefully controlled doses of ketamine to relieve symptoms of depression and other mood disorders. Originally introduced decades ago as a safe surgical anaesthetic, ketamine has since been studied extensively for its effects on mood. At our Manhattan clinic, every dose is administered and monitored by board-certified psychiatrists in a calm, clinical setting.
What makes ketamine different is how it works in the brain. Most
antidepressants target the serotonin system and can take four to six weeks tomake a difference. Ketamine acts on the brain's glutamate and NMDA
receptor system, which is believed to promote neuroplasticity, the brain's
ability to form new neural connections. This mechanism is one reason
ketamine can sometimes help people who have not responded to traditional
medications.
For New Yorkers across Manhattan, Brooklyn, Queens, and northern New
Jersey, ketamine for OCD in New York City offers another evidence-
based option when standard treatments have fallen short. It is not a quick fix
or a take-home prescription. It is a supervised medical treatment delivered aspart of a personalised plan.
Ketamine's antidepressant effects have been studied in numerous peer-
reviewed trials, and esketamine (Spravato®) is FDA-approved for treatment-resistant depression.
We offer IV, IM, and Spravato under one roof, so your psychiatrist can match the
right approach to your situation.
IV INFUSION
Direct delivery into the bloodstream provides rapid relief from OCD symptoms, ideal for treatment-resistant OCD. Each 40-minute session is monitored for heart rate and blood pressure to ensure safety and comfort.
Nasal Spray
FDA-approved nasal spray therapy shown to help OCD patients and those with major depressive disorder. Sessions are supervised by healthcare professionals and follow strict safety standards.
IM INJECTION
A reliable option that offers lasting relief from intrusive thoughts and compulsive behaviors without IV infusions. IM therapy helps maintain stability between dosing sessions.
Spravato® (esketamine) is a nasal spray derived from ketamine. It is FDA-approved for treatment-resistant depression in adults, used together with an oral antidepressant. It is also approved for depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behaviour.
Because of its profile, Spravato must be administered in a healthcare setting certified under the FDA's REMS (Risk Evaluation and Mitigation Strategy) program. After each dose, patients are monitored on-site for at least two hours and cannot drive for the rest of that day, so you will need to arrange a ride home.
This in-clinic model is also why Spravato is more frequently covered by insurance than IV or IM ketamine, which are typically used off-label. Candidates are generally adults whose depression has not responded adequately to other antidepressants. A psychiatrist will onfirm whether it is appropriate for you.
A side-by-side look to help you and your psychiatrist choose the right path.
| Treatment | How it's given |
Typical session length |
FDA status |
Insurance likelihood |
Best suited for |
|---|---|---|---|---|---|
|
IV Infusion |
Slow intravenous drip, in-clinic |
~40 min, plus
monitoring |
Off-label for
mood disorders |
Often self-pay / out-of-network |
Rapid relief, treatment-resistant depression, certain chronic pain |
|
IM Injection |
Intramuscular injection, in-clinic |
~40 min, plus
monitoring |
Off-label for
mood disorders |
Usually self-pay |
A simpler alternative to IV for some patients |
|
Spravato® Nasal Spray |
Self-administered nasal spray under supervision |
Dose plus ~2 hr monitoring |
FDA-approved for TRD |
More often covered by insurance |
Treatment-resistant depression, alongside an oral antidepressant |
IV and IM ketamine are used off-label and are frequently self-pay. Spravato is FDA-approved and, because it is given in-clinic, is more often covered. We verify your specific coverage for free.
Works within hours, helping ease obsessive thoughts and anxiety before they escalate.
Extensive systematic reviews and clinical trials show that ketamine works by modulating NMDA receptors and restoring balance in the glutamate system.
Every session is administered in person by board-certified psychiatrists in a controlled clinical setting, with vital-sign monitoring throughout.
All sessions occur in a secure therapeutic setting under professional supervision. Our low-dose protocols reduce dissociative effects
Find us at our Manhattan clinic and we review your medical history, OCD symptoms, and personal goals, then design a treatment plan tailored to your needs.
Choose from IV ketamine, intranasal ketamine, or IM therapy. We adjust administration for optimal response for each patient.
You're cared for in a
comfortable setting with vitals
tracked throughout each
session.
After your ketamine sessions, our therapists guide response prevention exercises to reinforce progress and apply new perspectives in daily life.
You begin with a consultation. We take a careful medical and psychiatric history, discuss your goals, and design a personalised protocol. We also verify your insurance coverage and answerany questions so you feel informed before anything begins.
You're seated comfortably in a quiet, monitored room. A typical session lasts around 40 minutes,
with vitals tracked throughout. Many patients notice a mild, transient sense of dissociation, a
floating or dreamlike feeling, that fades as the session ends. Our team is present the entire time.
Because of the temporary effects, you should not drive on a treatment day, so arrange a ride
home in advance. Many patients benefit from optional integration or therapy support to help
translate the experience into lasting change.
Treatment usually starts with an initial series of sessions, followed by maintenance visits as
clinically indicated. Your psychiatrist tracks your response and adjusts the plan over time, rather
than following a fixed one-size-fits-all schedule.
Clinical findings show that patients experience a significant reduction in symptoms associated with major depression, bipolar disorder, and anxiety disorders. This evidence highlights ketamine therapy as an effective treatment for complex psychiatric disorders and treatment-resistant OCD.
Our low-dose ketamine treatment protocols prioritize safety and control. Some patients experience mild dissociative effects, but these fade quickly. Throughout each session, clinicians monitor vital signs, including heart rate and blood
pressure, to ensure stability.
Unlike higher doses used in anesthesia, our carefully managed ketamine dosing avoids dependency or adverse effects. Every session takes place under the supervision of experienced physicians who specialize in mental health care and pharmacological treatments.
All sessions are monitored by board-certified psychiatrists. Screening determines whether ketamine is appropriate for you.
TMS & Ketamine therapy and evidence-based care for:
Including treatment-resistant depression —
the primary FDA-approved use of TMS.
FDA-approved deep TMS protocol for OCD
when therapy alone hasn't worked.
FDA-approved for depression with co-
occurring anxiety symptoms.
FDA-approved deep TMS protocol for
nicotine addiction.
Board-certified psychiatrists with decades of experience treating depression, OCD,
and anxiety.
I founded Village TMS because so many of my patients had been failed by
standard treatment paths. My approach is unhurried, evidence-driven, and centred on what each person actually needs to feel like themselves again.
I came to TMS after watching patients
cycle through medications that didn't fit them. My focus is precision, matching the right protocol to the right person, and adjusting as we go.
I help adults and couples build self-awareness and deepen relationships. My work is grounded in Gestalt therapy and informed by EMDR, mindfulness, and transpersonal psychology. I combine deep emotional exploration with practical tools, working in a warm, collaborative space where clients feel genuinely seen and supported.
Everything you need to know before your free consultation.
Ketamine influences glutamate receptors, helping to rebalance disrupted brain signaling that drives obsessive thoughts and compulsive behaviors. By increasing gamma-aminobutyric acid activity and neuroplasticity, it helps the brain form healthier connections. Clinical research studies and systematic reviews have documented improvements in Yale-Brown Obsessive-Compulsive Scale scores and a rapid reduction in suicidal ideation.
Yes. In a controlled Ketamine Clinic, each session is carefully supervised. We use low doses and monitor vital signs like blood pressure to ensure safety. Studies have found that ketamine infusion therapy produces few adverse effects when administered by qualified clinicians.
Ketamine therapy offers new hope for those with treatment-resistant OCD or severe OCD. It provides relief when traditional treatments or cognitive behavioral therapy fail to improve OCD symptoms. Research demonstrates that even patients with long-standing resistant OCD show measurable gains within weeks.
Yes. Along with OCD, ketamine therapy has shown promising results for treatment-resistant depression, bipolar disorder, post-traumatic stress disorder, and eating disorders. These findings are supported by multiple case reports and systematic reviews.
During your first time, our clinicians explain the treatment method, monitor your comfort, and ensure you feel supported throughout the process. Sessions take place in a calm, private environment designed to encourage relaxation and personal growth.
The Yale-Brown Obsessive-Compulsive Scale is a clinical tool used to measure the severity of OCD symptoms. Studies consistently show dramatic decreases in these scores after a full course of ketamine therapy, reflecting meaningful relief for OCD patients.
OCD involves abnormal glutamate levels, a key neurotransmitter affecting mood and behavior. Ketamine’s effects on the glutamate receptor help reduce OCD thoughts, minimize handwashing or checking urges, and improve cognitive flexibility—something Pharmacological Treatments rarely achieve as quickly.
A controlled crossover trial of ketamine and several systematic reviews confirm that ketamine produces promising results in OCD treatment. An assistant professor at Yale University noted improved response prevention and reduced suicidal ideation in patients who had failed alternative treatments. These results highlight the strong efficacy of ketamine for those seeking life-changing recovery options.
When delivered in a clinical environment, ketamine is considered very safe. Our team maintains close monitoring of vital signs, prevents high doses, and ensures that no risk of substance abuse or misuse occurs under our supervision. Many patients find that ketamine-assisted psychotherapy complements ongoing care rather than replacing it.
For some people with treatment-resistant OCD, yes. Clinical studies using the Yale-Brown Obsessive-Compulsive Scale have documented meaningful reductions in symptoms, sometimes within hours or days. It works differently from SSRIs: instead of acting on serotonin over several weeks, ketamine acts on the brain’s glutamate system and supports neuroplasticity, which may help loosen the rigid thought-and-behavior loops that drive OCD. It is not a cure and does not work for everyone, which is why a psychiatric evaluation comes first.
Ketamine is used off-label for OCD. It is not FDA-approved specifically for OCD, and no ketamine formulation currently is. Spravato (esketamine) is FDA-approved, but for treatment-resistant depression, not OCD. Off-label use is legal, common in psychiatry, and appropriate when supervised by a qualified physician, we are simply clear about what the evidence and the approvals actually say.
The medication and the safety monitoring are the same, but the treatment goal and the response pattern differ. OCD often needs the ketamine work paired with therapy, particularly exposure and response prevention (ERP), to turn the short neuroplastic window into lasting change. During your consultation we assess whether ketamine alone, or ketamine combined with structured therapy, is the better fit for your OCD.
Yes. Both case reports and large research studies confirm ketamine as an effective treatment for OCD patients who don’t respond to SSRIs or therapy alone. The use of ketamine has revolutionized modern mental health treatment by offering faster results and higher success rates.
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