Physician-led ketamine for bipolar NYC, in Manhattan, for treatment-resistant depression, PTSD, anxiety, OCD, and more. IV ketamine, IM injections, and FDA-approved Spravato®, each delivered and monitored by board-certified psychiatrists.
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Dr Fradkin helped me with treatment-resistant depression using TMS.
Valery Dinner Verified Google ReviewI had a great experience at the Village TMS Center for Autism and Depression. The staff is very kind, professional, and truly cares about their patients. They take the time to listen and explain the treatment process clearly.
kibriyo komilova Verified Google ReviewMy son just finished TMS therapy with Village Group Medical. I am pleased to mention pleasant and welcoming atmosphere of this office. It helped my son relax and agree to undergo the therapy.
Yelena Haskin Verified Google ReviewVery professional and caring team. I enjoyed learning more about this solution and was pleased with the provided service!
Raul Ifraimov Verified Google ReviewTMS session with George went great. Even though I just started and it’s a new experience for me, a cautious supervision and guidance of the specialist helps to get through. I had all my questions being answered before the procedure. Will come again!
Ekaterina Kokovikhina Verified Google ReviewJust had my first TMS session. Feeling great!
Sofia Dro Verified Google ReviewDr Fradkin helped me with treatment-resistant depression using TMS.
Valery Dinner Verified Google Review
Ketamine assisted therapy is a modern psychiatric treatment that uses low,
carefully controlled doses of ketamine to relieve symptoms of depression and other mood disorders. Originally introduced decades ago as a safe surgical anaesthetic, ketamine has since been studied extensively for its effects on mood. At our Manhattan clinic, every dose is administered and monitored by board-certified psychiatrists in a calm, clinical setting.
What makes ketamine different is how it works in the brain. Most
antidepressants target the serotonin system and can take four to six weeks tomake a difference. Ketamine acts on the brain's glutamate and NMDA
receptor system, which is believed to promote neuroplasticity, the brain's
ability to form new neural connections. This mechanism is one reason
ketamine can sometimes help people who have not responded to traditional
medications.
For New Yorkers across Manhattan, Brooklyn, Queens, and northern New
Jersey, ketamine for bipolar in New York City offers another evidence-
based option when standard treatments have fallen short. It is not a quick fix
or a take-home prescription. It is a supervised medical treatment delivered aspart of a personalised plan.
Ketamine's antidepressant effects have been studied in numerous peer-
reviewed trials, and esketamine (Spravato®) is FDA-approved for treatment-resistant depression.
We offer IV, IM, and Spravato under one roof, so your psychiatrist can match the
right approach to your situation.
IV INFUSION
Direct delivery into the bloodstream offers fast-acting relief for bipolar patients experiencing severe depressive episodes. Each 40-minute intravenous infusion is continuously monitored for vital signs.
Nasal Spray
This FDA-approved ketamine treatment is ideal for those with treatment-resistant depression and bipolar. Sessions are safe, supervised by an experienced provider, and follow strict guidelines from the FDA.
IM INJECTION
A practical and effective option for patients seeking sustained relief. Our IM approach supports mood stability and helps reduce bipolar depression between visits without the need for IV infusions.
Spravato® (esketamine) is a nasal spray derived from ketamine. It is FDA-approved for treatment-resistant depression in adults, used together with an oral antidepressant. It is also approved for depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behaviour.
Because of its profile, Spravato must be administered in a healthcare setting certified under the FDA's REMS (Risk Evaluation and Mitigation Strategy) program. After each dose, patients are monitored on-site for at least two hours and cannot drive for the rest of that day, so you will need to arrange a ride home.
This in-clinic model is also why Spravato is more frequently covered by insurance than IV or IM ketamine, which are typically used off-label. Candidates are generally adults whose depression has not responded adequately to other antidepressants. A psychiatrist will onfirm whether it is appropriate for you.
A side-by-side look to help you and your psychiatrist choose the right path.
| Treatment | How it's given |
Typical session length |
FDA status |
Insurance likelihood |
Best suited for |
|---|---|---|---|---|---|
|
IV Infusion |
Slow intravenous drip, in-clinic |
~40 min, plus
monitoring |
Off-label for
mood disorders |
Often self-pay / out-of-network |
Rapid relief, treatment-resistant depression, certain chronic pain |
|
IM Injection |
Intramuscular injection, in-clinic |
~40 min, plus
monitoring |
Off-label for
mood disorders |
Usually self-pay |
A simpler alternative to IV for some patients |
|
Spravato® Nasal Spray |
Self-administered nasal spray under supervision |
Dose plus ~2 hr monitoring |
FDA-approved for TRD |
More often covered by insurance |
Treatment-resistant depression, alongside an oral antidepressant |
IV and IM ketamine are used off-label and are frequently self-pay. Spravato is FDA-approved and, because it is given in-clinic, is more often covered. We verify your specific coverage for free.
Unlike traditional antidepressants, Ketamine works within hours to reduce depressive symptoms and restore calm after manic episodes or emotional lows.
Peer-reviewed studies report meaningful reductions in bipolar depressive symptoms and rapid decreases in suicidal ideation, including those who have not responded to standard treatment.
Our treatment protocols combine medication with therapy services, mindfulness, and integration work to help each bipolar patient maintain long-term mood stabilization.
Every ketamine treatment is supervised by board-certified psychiatrists. Low doses are used to avoid adverse effects, ensuring a safe, professional, and comfortable environment.
Find us in our Manhattan office and begin with a full review of your treatment history, family history, and goals. Together, we’ll design a tailored bipolar treatment plan.
Every approach is tailored to your individual treatment resistance and monitored for safety and response.
You're cared for in a
comfortable setting with vitals
tracked throughout each
session.
We provide supportive therapy services to reinforce insights, encourage mood stability, and apply healing strategies to daily life.
You begin with a consultation. We take a careful medical and psychiatric history, discuss your goals, and design a personalised protocol. We also verify your insurance coverage and answerany questions so you feel informed before anything begins.
You're seated comfortably in a quiet, monitored room. A typical session lasts around 40 minutes,
with vitals tracked throughout. Many patients notice a mild, transient sense of dissociation, a
floating or dreamlike feeling, that fades as the session ends. Our team is present the entire time.
Because of the temporary effects, you should not drive on a treatment day, so arrange a ride
home in advance. Many patients benefit from optional integration or therapy support to help
translate the experience into lasting change.
Treatment usually starts with an initial series of sessions, followed by maintenance visits as
clinically indicated. Your psychiatrist tracks your response and adjusts the plan over time, rather
than following a fixed one-size-fits-all schedule.
Research shows that Ketamine Infusion Therapy rapidly enhances activity in the prefrontal cortex, improving cognitive function and emotional control. By
targeting the NMDA receptor and AMPA receptors, ketamine restores normal
signaling in the brain’s neural circuits, helping manage bipolar disorder
symptoms and break cycles of depression.
Our protocols prioritize safety above all. During every infusion of ketamine,
clinicians monitor your blood pressure, respiratory rate, and overall comfort.
Low-dose methods minimize adverse effects like dizziness or mild dissociation.
Unlike Traditional mood stabilizers, ketamine does not require daily use and
poses no risk of substance abuse. Experts in psychiatric disorders
guide sessions to ensure long-term safety and positive outcomes.
All sessions are monitored by board-certified psychiatrists. Screening determines whether ketamine is appropriate for you.
TMS & Ketamine therapy and evidence-based care for:
Including treatment-resistant depression —
the primary FDA-approved use of TMS.
FDA-approved deep TMS protocol for OCD
when therapy alone hasn't worked.
FDA-approved for depression with co-
occurring anxiety symptoms.
FDA-approved deep TMS protocol for
nicotine addiction.
Board-certified psychiatrists with decades of experience treating depression, OCD,
and anxiety.
I founded Village TMS because so many of my patients had been failed by
standard treatment paths. My approach is unhurried, evidence-driven, and centred on what each person actually needs to feel like themselves again.
I came to TMS after watching patients
cycle through medications that didn't fit them. My focus is precision, matching the right protocol to the right person, and adjusting as we go.
I help adults and couples build self-awareness and deepen relationships. My work is grounded in Gestalt therapy and informed by EMDR, mindfulness, and transpersonal psychology. I combine deep emotional exploration with practical tools, working in a warm, collaborative space where clients feel genuinely seen and supported.
Everything you need to know before your free consultation.
Bipolar depression is genuinely hard to treat, and for a specific reason. Many conventional antidepressants carry a risk of mood switching, they can tip a bipolar patient into a manic or mixed episode. That is part of why the depressive phase of bipolar often goes undertreated. Ketamine works differently: rather than acting on serotonin over weeks, it targets the brain’s glutamate system and NMDA receptors and supports rapid neuroplasticity, and some patients notice improvement in depressive symptoms within hours to days. Because bipolar carries that mood-switch risk, we deliver ketamine with careful screening and in coordination with your existing mood stabilizers, never as a stand-alone antidepressant.
Yes. In a clinical setting, ketamine therapy is safe and well-tolerated. Each session monitors vital signs, including heart rate and blood pressure, to ensure stability. Unlike Traditional treatments, low-dose infusions have minimal adverse effects and no risk of substance use dependency.
Ketamine for Bipolar is effective for both Bipolar I and bipolar depression. It helps balance mood instability, reduce suicidal ideation, and support long-term mood stabilization under a psychiatrist’s supervision.
Unlike traditional antidepressants, which can take weeks, ketamine treatment produces immediate effects. It activates AMPA receptors and enhances communication in the prefrontal cortex, creating faster and longer-lasting relief for treatment-resistant depression and resistant depression.
Both ECT and Ketamine Infusion Therapy are proven methods for severe depressive states, but ketamine provides faster results with fewer adverse effects. Many patients prefer it as a more comfortable bipolar treatment alternative.
The main benefits of ketamine include reduced depressive symptoms, improved mood stability, and decreased suicidal thoughts. For many, it’s the first step toward lasting mood regulation and emotional recovery.
Yes. Regular maintenance treatment can help sustain mood stabilization and minimize the risk of recurring manic episodes or severe depressive episodes. These sessions are part of a comprehensive approach to long-term recovery.
Mild adverse effects such as lightheadedness or temporary dissociation may occur but fade quickly. Our clinicians track your vital signs to prevent complications and ensure every infusion of ketamine is safe and controlled.
Those with bipolar depression, treatment-resistant depression, or a Family History of mood disorders may benefit most. A consultation helps determine if you are a bipolar patient suitable for treatment at our ketamine infusion clinics.
Ketamine’s effects involve the use of ketamine to block the NMDA receptor, which helps repair damaged neural circuits. This improves mood, reduces suicidal ideation, and supports long-term recovery from psychiatric disorders and other mental illnesses.
This is the right question to ask. Standard antidepressants can trigger mood switching into mania, which is a real risk in bipolar disorder. Current evidence suggests ketamine has a lower manic-switch risk than conventional antidepressants, but the risk is not zero, so it should only be given under psychiatric supervision, with screening and in coordination with your mood stabilizers. We monitor for any signs of elevated mood throughout your treatment course.
For some patients, yes, and specifically for the depressive phase of bipolar, not for mania. Studies show measurable improvement in depressive symptoms, sometimes within hours to days, which is far faster than the weeks mood stabilizers or antidepressants typically take. It is used when the depressive episodes have not responded to standard treatment, and it works alongside your existing medications rather than replacing them.
Ketamine is used off-label for bipolar depression, it is not FDA-approved specifically for bipolar, and IV ketamine is generally not covered by insurance. Spravato (esketamine) is FDA-approved, but for treatment-resistant depression, not bipolar. Off-label use is legal and common in psychiatry when supervised by a qualified physician. We are clear about costs and coverage during your consultation so there are no surprises.
While primarily used for bipolar treatment, research shows it may also assist individuals managing personality disorder or substance use problems. By enhancing cognitive function and resilience, ketamine supports broader mental health conditions.
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